Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

Liliana Losada; Janyce A. Sugui; Michael A. Eckhaus; Yun C. Chang; Stephanie Mounaud; Abigail Figat; Vinita Joardar; Suman B. Pakala; Suchitra Pakala; Pratap Venepally; Natalie Fedorova; William C. Nierman; Kyung J. Kwon-Chung

doi:10.1371/journal.ppat.1004834

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Peer-reviewed

Research Article

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

Liliana Losada ,

Contributed equally to this work with: Liliana Losada, Janyce A. Sugui

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America
⨯
Janyce A. Sugui ,

Contributed equally to this work with: Liliana Losada, Janyce A. Sugui

Affiliation Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Michael A. Eckhaus,

Affiliation Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yun C. Chang,

Affiliation Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Stephanie Mounaud,

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America
⨯
Abigail Figat,

Affiliation Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Vinita Joardar,

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America
⨯
Suman B. Pakala,

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America
⨯
Suchitra Pakala,

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America
⨯
Pratap Venepally,

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America
⨯
Natalie Fedorova,

Affiliation National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
William C. Nierman,

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America
⨯
Kyung J. Kwon-Chung

* E-mail: jkchung@nih.gov

Affiliation Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

Liliana Losada,
Janyce A. Sugui,
Michael A. Eckhaus,
Yun C. Chang,
Stephanie Mounaud,
Abigail Figat,
Vinita Joardar,
Suman B. Pakala,
Suchitra Pakala,
Pratap Venepally

Published: April 24, 2015
https://doi.org/10.1371/journal.ppat.1004834

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