The EBNA3 Family of Epstein-Barr Virus Nuclear Proteins Associates with the USP46/USP12 Deubiquitination Complexes to Regulate Lymphoblastoid Cell Line Growth

Makoto Ohashi; Amy M. Holthaus; Michael A. Calderwood; Chiou-Yan Lai; Bryan Krastins; David Sarracino; Eric Johannsen

doi:10.1371/journal.ppat.1004822

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Peer-reviewed

Research Article

The EBNA3 Family of Epstein-Barr Virus Nuclear Proteins Associates with the USP46/USP12 Deubiquitination Complexes to Regulate Lymphoblastoid Cell Line Growth

Makoto Ohashi ,

Contributed equally to this work with: Makoto Ohashi, Amy M. Holthaus

Affiliation Departments of Medicine and Oncology (McArdle Laboratory for Cancer Research), University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Amy M. Holthaus ,

Contributed equally to this work with: Makoto Ohashi, Amy M. Holthaus

Affiliation Infectious Disease Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Michael A. Calderwood,

Current address: Center for Cancer Systems Biology (CCCSB) and Department of Cancer Biology, Dana-Faber Cancer Institute, Boston, Massachusetts, United States of America

Affiliation Infectious Disease Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Chiou-Yan Lai,

Current address: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Affiliation Infectious Disease Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Bryan Krastins,

Affiliation Biomarker Research Initiatives in Mass Spectrometry (BRIMS), Thermo Fisher Scientific, Cambridge, Massachusetts, United States of America
⨯
David Sarracino,

Affiliation Biomarker Research Initiatives in Mass Spectrometry (BRIMS), Thermo Fisher Scientific, Cambridge, Massachusetts, United States of America
⨯
Eric Johannsen

* E-mail: ejohannsen@medicine.wisc.edu

Affiliation Departments of Medicine and Oncology (McArdle Laboratory for Cancer Research), University of Wisconsin, Madison, Wisconsin, United States of America
⨯

The EBNA3 Family of Epstein-Barr Virus Nuclear Proteins Associates with the USP46/USP12 Deubiquitination Complexes to Regulate Lymphoblastoid Cell Line Growth

Makoto Ohashi,
Amy M. Holthaus,
Michael A. Calderwood,
Chiou-Yan Lai,
Bryan Krastins,
David Sarracino,
Eric Johannsen

Published: April 9, 2015
https://doi.org/10.1371/journal.ppat.1004822

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