Lipidomic Analysis Links Mycobactin Synthase K to Iron Uptake and Virulence in M. tuberculosis

Cressida A. Madigan; Amanda Jezek Martinot; Jun-Rong Wei; Ashoka Madduri; Tan-Yun Cheng; David C. Young; Emilie Layre; Jeffrey P. Murry; Eric J. Rubin; D. Branch Moody

doi:10.1371/journal.ppat.1004792

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Open Access

Peer-reviewed

Research Article

Lipidomic Analysis Links Mycobactin Synthase K to Iron Uptake and Virulence in M. tuberculosis

Cressida A. Madigan,

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Amanda Jezek Martinot ,

Contributed equally to this work with: Amanda Jezek Martinot, Jun-Rong Wei

Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Jun-Rong Wei ,

Contributed equally to this work with: Amanda Jezek Martinot, Jun-Rong Wei

Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Ashoka Madduri,

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Tan-Yun Cheng,

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
David C. Young,

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Emilie Layre,

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jeffrey P. Murry,

Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Eric J. Rubin,

Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
D. Branch Moody

* E-mail: bmoody@rics.bwh.harvard.edu

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Lipidomic Analysis Links Mycobactin Synthase K to Iron Uptake and Virulence in M. tuberculosis

Cressida A. Madigan,
Amanda Jezek Martinot,
Jun-Rong Wei,
Ashoka Madduri,
Tan-Yun Cheng,
David C. Young,
Emilie Layre,
Jeffrey P. Murry,
Eric J. Rubin,
D. Branch Moody

Published: March 27, 2015
https://doi.org/10.1371/journal.ppat.1004792

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