NEDDylation Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus Latency and Lytic Reactivation and Represents a Novel Anti-KSHV Target

Open Access

Peer-reviewed

Research Article

David J. Hughes ,

* E-mail: djh25@st-andrews.ac.uk (DJH); a.whitehouse@leeds.ac.uk (AW)

Current address: Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, Fife,United Kingdom

Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
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Jennifer J. Wood,

Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
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Brian R. Jackson,

Affiliations School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
⨯
Belinda Baquero-Pérez,

Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
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Adrian Whitehouse

* E-mail: djh25@st-andrews.ac.uk (DJH); a.whitehouse@leeds.ac.uk (AW)

Affiliations School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
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Viral replication
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DNA replication
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Transcription factors
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Lytic cycle
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Gene expression
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Kaposi's sarcoma-associated herpesvirus
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Cancer treatment
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Viral gene expression
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