Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase

Junjie Zhang; Shanping He; Yi Wang; Kevin Brulois; Ke Lan; Jae U. Jung; Pinghui Feng

doi:10.1371/journal.ppat.1004768

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Open Access

Peer-reviewed

Research Article

Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase

Junjie Zhang,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Shanping He,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Yi Wang,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Kevin Brulois,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Ke Lan,

Affiliation Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, P.R. China
⨯
Jae U. Jung,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Pinghui Feng

* E-mail: pinghui.feng@usc.edu

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯

Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase

Junjie Zhang,
Shanping He,
Yi Wang,
Kevin Brulois,
Ke Lan,
Jae U. Jung,
Pinghui Feng

Published: March 26, 2015
https://doi.org/10.1371/journal.ppat.1004768

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G protein coupled receptors
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Transfection
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Cancers and neoplasms
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Kaposi's sarcoma-associated herpesvirus
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293T cells
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Immunoblotting
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Gene expression
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