Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

Joseph N. Jarvis; Graeme Meintjes; Tihana Bicanic; Viviana Buffa; Louise Hogan; Stephanie Mo; Gillian Tomlinson; Pascale Kropf; Mahdad Noursadeghi; Thomas S. Harrison

doi:10.1371/journal.ppat.1004754

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Peer-reviewed

Research Article

Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

Joseph N. Jarvis ,

* E-mail: drjoejarvis@gmail.com

Affiliations Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Botswana-UPenn Partnership, Gaborone, Botswana, Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
⨯
Graeme Meintjes,

Affiliations Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, South Africa, Department of Medicine, Imperial College London, London, United Kingdom
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Tihana Bicanic,

Affiliation Research Centre for Infection and Immunity, Division of Clinical Sciences, St. George’s University of London, London, United Kingdom
⨯
Viviana Buffa,

Affiliation Research Centre for Infection and Immunity, Division of Clinical Sciences, St. George’s University of London, London, United Kingdom
⨯
Louise Hogan,

Affiliation Research Centre for Infection and Immunity, Division of Clinical Sciences, St. George’s University of London, London, United Kingdom
⨯
Stephanie Mo,

Affiliation Department of Medicine, Imperial College London, London, United Kingdom
⨯
Gillian Tomlinson,

Affiliation Division of Infection and Immunity, University College London, London, United Kingdom
⨯
Pascale Kropf,

Affiliation Department of Medicine, Imperial College London, London, United Kingdom
⨯
Mahdad Noursadeghi,

Affiliation Division of Infection and Immunity, University College London, London, United Kingdom
⨯
Thomas S. Harrison

Affiliation Research Centre for Infection and Immunity, Division of Clinical Sciences, St. George’s University of London, London, United Kingdom
⨯

Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

Joseph N. Jarvis,
Graeme Meintjes,
Tihana Bicanic,
Viviana Buffa,
Louise Hogan,
Stephanie Mo,
Gillian Tomlinson,
Pascale Kropf,
Mahdad Noursadeghi,
Thomas S. Harrison

Published: April 8, 2015
https://doi.org/10.1371/journal.ppat.1004754

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Cytokines
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Cerebrospinal fluid
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Chemokines
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Cryptococcus
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