The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

• Lonneke van der Linden,

  Current address: Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  Affiliations Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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• Laia Vives-Adrián,

  Affiliation Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain

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• Barbara Selisko,

  Affiliation AFMB UMR 7257, Aix-Marseille Université & CNRS, Marseille, France

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• Cristina Ferrer-Orta,

  Affiliation Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain

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• Xinran Liu,

  Affiliation Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Kjerstin Lanke,

  Affiliation Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Rachel Ulferts,

  Affiliations Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands, Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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• Armando M. De Palma,

  Affiliation Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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• Federica Tanchis,

  Affiliation Abteilung Pharmazeutische Chemie, Institut für Pharmazie, Universität Innsbruck, Innsbruck, Austria

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• Nesya Goris,

  Current address: Aratana Therapeutics NV, Heverlee, Belgium

  Affiliation Okapi Sciences NV, Heverlee, Belgium

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• David Lefebvre,

  Affiliation Unit of Vesicular and Exotic Diseases, Virology Department, CODA-CERVA, Veterinary and Agrochemical Research Centre, Brussels, Belgium

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• Kris De Clercq,

  Affiliation Unit of Vesicular and Exotic Diseases, Virology Department, CODA-CERVA, Veterinary and Agrochemical Research Centre, Brussels, Belgium

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• Pieter Leyssen,

  Affiliation Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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• Céline Lacroix,

  Affiliation Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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• Gerhard Pürstinger,

  Affiliation Abteilung Pharmazeutische Chemie, Institut für Pharmazie, Universität Innsbruck, Innsbruck, Austria

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• Bruno Coutard,

  Affiliation AFMB UMR 7257, Aix-Marseille Université & CNRS, Marseille, France

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• Bruno Canard,

  Affiliation AFMB UMR 7257, Aix-Marseille Université & CNRS, Marseille, France

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• David D. Boehr,

  Affiliation Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Jamie J. Arnold,

  Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Craig E. Cameron,

  Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Nuria Verdaguer,

  Affiliation Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain

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• Johan Neyts ,

  Contributed equally to this work with: Johan Neyts, Frank J. M. van Kuppeveld

  Affiliation Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

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•  [ ... ],
• Frank J. M. van Kuppeveld

  Contributed equally to this work with: Johan Neyts, Frank J. M. van Kuppeveld

  * E-mail: F.J.M.vanKuppeveld@uu.nl

  Affiliations Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands, Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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