Metalloprotease NleC Suppresses Host NF-κB/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction

• Andrea Hodgson ,

  Contributed equally to this work with: Andrea Hodgson, Eric M. Wier

  Affiliations W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Eric M. Wier ,

  Contributed equally to this work with: Andrea Hodgson, Eric M. Wier

  Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Kai Fu,

  Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Xin Sun,

  Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Hongbing Yu,

  Affiliation Division of Gastroenterology, Department of Pediatrics, BC’s Children’s Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada

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• Wenxin Zheng,

  Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Ho Pan Sham,

  Affiliation Division of Gastroenterology, Department of Pediatrics, BC’s Children’s Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada

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• Kaitlin Johnson,

  Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Scott Bailey,

  Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Bruce A. Vallance,

  Affiliation Division of Gastroenterology, Department of Pediatrics, BC’s Children’s Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada

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• Fengyi Wan

  * E-mail: fwan1@jhu.edu

  Affiliations Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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