Interaction between the Type III Effector VopO and GEF-H1 Activates the RhoA-ROCK Pathway

Hirotaka Hiyoshi; Ryu Okada; Shigeaki Matsuda; Kazuyoshi Gotoh; Yukihiro Akeda; Tetsuya Iida; Toshio Kodama

doi:10.1371/journal.ppat.1004694

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Open Access

Peer-reviewed

Research Article

Interaction between the Type III Effector VopO and GEF-H1 Activates the RhoA-ROCK Pathway

Hirotaka Hiyoshi,

Current address: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, United States of America

Affiliation Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
⨯
Ryu Okada,

Affiliation Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
⨯
Shigeaki Matsuda,

Affiliation Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
⨯
Kazuyoshi Gotoh,

Current address: Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan

Affiliation Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
⨯
Yukihiro Akeda,

Affiliation Laboratory of Clinical Research on Infectious Diseases, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
⨯
Tetsuya Iida,

Affiliation Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
⨯
Toshio Kodama

* E-mail: kodama@biken.osaka-u.ac.jp

Affiliation Microbe Repository Unit, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
⨯

Interaction between the Type III Effector VopO and GEF-H1 Activates the RhoA-ROCK Pathway

Hirotaka Hiyoshi,
Ryu Okada,
Shigeaki Matsuda,
Kazuyoshi Gotoh,
Yukihiro Akeda,
Tetsuya Iida,
Toshio Kodama

Published: March 4, 2015
https://doi.org/10.1371/journal.ppat.1004694

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