A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

• Yongqian Zhao,

  Affiliations Program in Emerging Infectious Diseases, DUKE-NUS Graduate Medical School, Singapore, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore

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• Tingjin Sherryl Soh,

  Affiliations School of Biological Sciences, Nanyang Technological University, Singapore, Novartis Institute for Tropical Diseases, Singapore

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• Jie Zheng,

  Affiliation School of Biological Sciences, Nanyang Technological University, Singapore

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• Kitti Wing Ki Chan,

  Affiliation Program in Emerging Infectious Diseases, DUKE-NUS Graduate Medical School, Singapore

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• Wint Wint Phoo,

  Affiliation Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

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• Chin Chin Lee,

  Affiliation Program in Emerging Infectious Diseases, DUKE-NUS Graduate Medical School, Singapore

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• Moon Y. F. Tay,

  Affiliation Program in Emerging Infectious Diseases, DUKE-NUS Graduate Medical School, Singapore

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• Kunchithapadam Swaminathan,

  Affiliations NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Department of Biological Sciences, National University of Singapore, Singapore

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• Tobias C. Cornvik,

  Affiliation School of Biological Sciences, Nanyang Technological University, Singapore

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• Siew Pheng Lim,

  Affiliation Novartis Institute for Tropical Diseases, Singapore

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• Pei-Yong Shi,

  Affiliation Novartis Institute for Tropical Diseases, Singapore

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• Julien Lescar ,

  * E-mail: julien@ntu.edu.sg (JL); subhash.vasudevan@duke-nus.edu.sg (SGV); luodahai@ntu.edu.sg (DL)

  Affiliations School of Biological Sciences, Nanyang Technological University, Singapore, UPMC UMRS CR7—CNRS ERL 8255-INSERM U1135 Centre d’Immunologie et des Maladies Infectieuses, Centre Hospitalier Universitaire Pitié-Salpêtrière, Faculté de Médecine Pierre et Marie Curie, Paris, France

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• Subhash G. Vasudevan ,

  * E-mail: julien@ntu.edu.sg (JL); subhash.vasudevan@duke-nus.edu.sg (SGV); luodahai@ntu.edu.sg (DL)

  Affiliations Program in Emerging Infectious Diseases, DUKE-NUS Graduate Medical School, Singapore, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore

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• Dahai Luo

  * E-mail: julien@ntu.edu.sg (JL); subhash.vasudevan@duke-nus.edu.sg (SGV); luodahai@ntu.edu.sg (DL)

  Affiliation Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

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