Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Dihydrobiopterin in Adult Falciparum Malaria: Association with Disease Severity, Impaired Microvascular Function and Increased Endothelial Activation

Tsin W. Yeo; Daniel A. Lampah; Enny Kenangalem; Emiliana Tjitra; Ric N. Price; J. Brice Weinberg; Keith Hyland; Donald L. Granger; Nicholas M. Anstey

doi:10.1371/journal.ppat.1004667

Loading metrics

Open Access

Peer-reviewed

Research Article

Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Dihydrobiopterin in Adult Falciparum Malaria: Association with Disease Severity, Impaired Microvascular Function and Increased Endothelial Activation

Tsin W. Yeo ,

* E-mail: tsin.yeo@menzies.edu.au

Affiliations Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore
⨯
Daniel A. Lampah,

Affiliation Menzies School of Health Research-National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia
⨯
Enny Kenangalem,

Affiliation Menzies School of Health Research-National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia
⨯
Emiliana Tjitra,

Affiliation National Institute of Health Research and Development, Jakarta, Indonesia
⨯
Ric N. Price,

Affiliations Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
J. Brice Weinberg,

Affiliation Duke University and VA Medical Centers, Durham, North Carolina, United States of America
⨯
Keith Hyland,

Affiliation Medical Neurogenetics LLC, Atlanta, Georgia, United States of America
⨯
Donald L. Granger,

Affiliation Division of Infectious Diseases, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, United States of America
⨯
Nicholas M. Anstey

Affiliations Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia
⨯

Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Dihydrobiopterin in Adult Falciparum Malaria: Association with Disease Severity, Impaired Microvascular Function and Increased Endothelial Activation

Tsin W. Yeo,
Daniel A. Lampah,
Enny Kenangalem,
Emiliana Tjitra,
Ric N. Price,
J. Brice Weinberg,
Keith Hyland,
Donald L. Granger,
Nicholas M. Anstey

Published: March 12, 2015
https://doi.org/10.1371/journal.ppat.1004667

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Malaria
Is the Subject Area "Malaria" applicable to this article?

Thanks for your feedback.
Nitric oxide
Is the Subject Area "Nitric oxide" applicable to this article?

Thanks for your feedback.
Phenylalanine
Is the Subject Area "Phenylalanine" applicable to this article?

Thanks for your feedback.
Creatinine
Is the Subject Area "Creatinine" applicable to this article?

Thanks for your feedback.
Metabolites
Is the Subject Area "Metabolites" applicable to this article?

Thanks for your feedback.
Urine
Is the Subject Area "Urine" applicable to this article?

Thanks for your feedback.
Malarial parasites
Is the Subject Area "Malarial parasites" applicable to this article?

Thanks for your feedback.
Severe sepsis
Is the Subject Area "Severe sepsis" applicable to this article?

Thanks for your feedback.