Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Oxidized Biopterins in Pediatric Falciparum Malaria: Association with Disease Severity

Matthew P. Rubach; Jackson Mukemba; Salvatore Florence; Bert K. Lopansri; Keith Hyland; Alicia D. Volkheimer; Tsin W. Yeo; Nicholas M. Anstey; J. Brice Weinberg; Esther D. Mwaikambo; Donald L. Granger

doi:10.1371/journal.ppat.1004655

Loading metrics

Open Access

Peer-reviewed

Research Article

Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Oxidized Biopterins in Pediatric Falciparum Malaria: Association with Disease Severity

Matthew P. Rubach,

Affiliation Department of Medicine, Duke University and VA Medical Centers, Durham, North Carolina, United States of America
⨯
Jackson Mukemba,

Affiliation Department of Pediatrics, Hubert Kairuki Memorial University, Dar es Salaam, United Republic of Tanzania
⨯
Salvatore Florence,

Affiliation Department of Pediatrics, Hubert Kairuki Memorial University, Dar es Salaam, United Republic of Tanzania
⨯
Bert K. Lopansri,

Affiliations Department of Medicine, Intermountain Healthcare, Salt Lake City, Utah, United States of America, Department of Medicine, University of Utah School of Medicine and VA Medical Center, Salt Lake City, Utah, United States of America
⨯
Keith Hyland,

Affiliation Neurochemistry Division, Medical Neurogenetics, Atlanta, Georgia, United States of America
⨯
Alicia D. Volkheimer,

Affiliation Department of Medicine, Duke University and VA Medical Centers, Durham, North Carolina, United States of America
⨯
Tsin W. Yeo,

Affiliations Global and Tropical Health Division, Menzies School for Health Research and Charles Darwin University, Darwin, Australia, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia, Department of Medicine, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
⨯
Nicholas M. Anstey,

Affiliations Global and Tropical Health Division, Menzies School for Health Research and Charles Darwin University, Darwin, Australia, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia
⨯
J. Brice Weinberg,

Affiliation Department of Medicine, Duke University and VA Medical Centers, Durham, North Carolina, United States of America
⨯
Esther D. Mwaikambo,

Affiliation Department of Pediatrics, Hubert Kairuki Memorial University, Dar es Salaam, United Republic of Tanzania
⨯
Donald L. Granger

* E-mail: Don.Granger@hsc.utah.edu

Affiliation Department of Medicine, University of Utah School of Medicine and VA Medical Center, Salt Lake City, Utah, United States of America
⨯

Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Oxidized Biopterins in Pediatric Falciparum Malaria: Association with Disease Severity

Matthew P. Rubach,
Jackson Mukemba,
Salvatore Florence,
Bert K. Lopansri,
Keith Hyland,
Alicia D. Volkheimer,
Tsin W. Yeo,
Nicholas M. Anstey,
J. Brice Weinberg,
Esther D. Mwaikambo

Published: March 12, 2015
https://doi.org/10.1371/journal.ppat.1004655

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cerebral malaria
Is the Subject Area "Cerebral malaria" applicable to this article?

Thanks for your feedback.
Urine
Is the Subject Area "Urine" applicable to this article?

Thanks for your feedback.
Malaria
Is the Subject Area "Malaria" applicable to this article?

Thanks for your feedback.
Nitric oxide
Is the Subject Area "Nitric oxide" applicable to this article?

Thanks for your feedback.
Creatinine
Is the Subject Area "Creatinine" applicable to this article?

Thanks for your feedback.
Phenylalanine
Is the Subject Area "Phenylalanine" applicable to this article?

Thanks for your feedback.
Blood plasma
Is the Subject Area "Blood plasma" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.