Disruption of an M. tuberculosis Membrane Protein Causes a Magnesium-dependent Cell Division Defect and Failure to Persist in Mice

Nichole Goodsmith; Xinzheng V. Guo; Omar H. Vandal; Julien Vaubourgeix; Ruojun Wang; Hélène Botella; Shuang Song; Kamlesh Bhatt; Amir Liba; Padmini Salgame; Dirk Schnappinger; Sabine Ehrt

doi:10.1371/journal.ppat.1004645

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Open Access

Peer-reviewed

Research Article

Disruption of an M. tuberculosis Membrane Protein Causes a Magnesium-dependent Cell Division Defect and Failure to Persist in Mice

Nichole Goodsmith,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Xinzheng V. Guo,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Omar H. Vandal,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Julien Vaubourgeix,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Ruojun Wang,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Hélène Botella,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Shuang Song,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Kamlesh Bhatt,

Affiliation Department of Medicine, Center for Emerging Pathogens, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Amir Liba,

Affiliation Agilent Technologies, Wilmington, Delaware, United States of America
⨯
Padmini Salgame,

Affiliation Department of Medicine, Center for Emerging Pathogens, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Dirk Schnappinger,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Sabine Ehrt

* E-mail: sae2004@med.cornell.edu

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯

Disruption of an M. tuberculosis Membrane Protein Causes a Magnesium-dependent Cell Division Defect and Failure to Persist in Mice

Nichole Goodsmith,
Xinzheng V. Guo,
Omar H. Vandal,
Julien Vaubourgeix,
Ruojun Wang,
Hélène Botella,
Shuang Song,
Kamlesh Bhatt,
Amir Liba,
Padmini Salgame

Published: February 6, 2015
https://doi.org/10.1371/journal.ppat.1004645

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Mycobacterium tuberculosis
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Macrophages
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Cell cycle and cell division
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Peptidoglycans
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Cell walls
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Biosynthesis
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Magnesium
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Gene expression
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