Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice

Susu Duan; Victoria A. Meliopoulos; Jennifer L. McClaren; Xi-Zhi J. Guo; Catherine J. Sanders; Heather S. Smallwood; Richard J. Webby; Stacey L. Schultz-Cherry; Peter C. Doherty; Paul G. Thomas

doi:10.1371/journal.ppat.1004642

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Open Access

Peer-reviewed

Research Article

Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice

Susu Duan,

Affiliation Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Victoria A. Meliopoulos,

Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Jennifer L. McClaren,

Affiliation Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Xi-Zhi J. Guo,

Affiliation Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Catherine J. Sanders,

Affiliation Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Heather S. Smallwood,

Affiliation Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Richard J. Webby,

Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Stacey L. Schultz-Cherry,

Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Peter C. Doherty,

Affiliation Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Paul G. Thomas

* E-mail: Paul.Thomas@stjude.org

Affiliation Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯

Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice

Susu Duan,
Victoria A. Meliopoulos,
Jennifer L. McClaren,
Xi-Zhi J. Guo,
Catherine J. Sanders,
Heather S. Smallwood,
Richard J. Webby,
Stacey L. Schultz-Cherry,
Peter C. Doherty,
Paul G. Thomas

Published: February 10, 2015
https://doi.org/10.1371/journal.ppat.1004642

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