The M3 Muscarinic Receptor Is Required for Optimal Adaptive Immunity to Helminth and Bacterial Infection

• Matthew Darby ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa

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• Corinna Schnoeller ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Department of Life Sciences, Sir Ernst Chain Building, South Kensington Campus, Imperial College London, London, United Kingdom

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• Alykhan Vira ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa

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• Fiona Culley,

  Affiliation National Heart and Lung Institute, St.Mary’s Campus, Praed Street, Imperial College London, London, United Kingdom

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• Saeeda Bobat,

  Affiliation Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom

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• Erin Logan,

  Affiliation Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa

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• Frank Kirstein,

  Affiliation Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa

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• Jürgen Wess,

  Affiliation Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Adam F. Cunningham,

  Affiliation Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom

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• Frank Brombacher,

  Affiliation Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa

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• Murray E. Selkirk ,

  * E-mail: wghorsnell@gmail.com (WGCH); m.selkirk@imperial.ac.uk (MES)

  Affiliation Department of Life Sciences, Sir Ernst Chain Building, South Kensington Campus, Imperial College London, London, United Kingdom

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• William G. C. Horsnell

  * E-mail: wghorsnell@gmail.com (WGCH); m.selkirk@imperial.ac.uk (MES)

  Affiliation Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa

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