Characterization of the Mycobacterial Acyl-CoA Carboxylase Holo Complexes Reveals Their Functional Expansion into Amino Acid Catabolism

• Matthias T. Ehebauer ,

  Current address: The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

  ¶‡ These authors contributed equally to this work.

  Affiliation European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany

  ⨯
• Michael Zimmermann ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland

  ⨯
• Arjen J. Jakobi,

  Affiliations European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany, European Molecular Biology Laboratory, Structural Biology and Computational Biology Programme, Heidelberg, Germany

  ⨯
• Elke E. Noens,

  Current address: Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands

  Affiliation European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany

  ⨯
• Daniel Laubitz,

  Current address: Department of Pediatrics, Steele Children’s Research Center, Arizona Health Sciences Center, University of Arizona, Tucson, Arizona, United States of America

  Affiliations Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland, Department of Genetics & Biotechnology, Warsaw University, Warsaw, Poland

  ⨯
• Bogdan Cichocki,

  Affiliations Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland, Department of Genetics & Biotechnology, Warsaw University, Warsaw, Poland

  ⨯
• Hedia Marrakchi,

  Affiliation Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Tuberculosis & Infection Biology Department, Toulouse, France; Université Paul Sabatier, Toulouse, France

  ⨯
• Marie-Antoinette Lanéelle,

  Affiliation Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Tuberculosis & Infection Biology Department, Toulouse, France; Université Paul Sabatier, Toulouse, France

  ⨯
• Mamadou Daffé,

  Affiliation Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Tuberculosis & Infection Biology Department, Toulouse, France; Université Paul Sabatier, Toulouse, France

  ⨯
• Carsten Sachse,

  Affiliation European Molecular Biology Laboratory, Structural Biology and Computational Biology Programme, Heidelberg, Germany

  ⨯
• Andrzej Dziembowski,

  Affiliations Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland, Department of Genetics & Biotechnology, Warsaw University, Warsaw, Poland

  ⨯
• Uwe Sauer,

  Affiliation Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland

  ⨯
• Matthias Wilmanns

  * E-mail: wilmanns@embl-hamburg.de

  Affiliations European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany, Center for Structural Systems Biology, Hamburg, Germany

  ⨯