Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

Anupam Jhingran; Shinji Kasahara; Kelly M. Shepardson; Beth A. Fallert Junecko; Lena J. Heung; Debra K. Kumasaka; Sue E. Knoblaugh; Xin Lin; Barbara I. Kazmierczak; Todd A. Reinhart; Robert A. Cramer; Tobias M. Hohl

doi:10.1371/journal.ppat.1004589

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Open Access

Peer-reviewed

Research Article

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

Anupam Jhingran,

Affiliation Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
⨯
Shinji Kasahara,

Affiliation Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
⨯
Kelly M. Shepardson,

Affiliation Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth University, Hanover, New Hampshire, United States of America
⨯
Beth A. Fallert Junecko,

Affiliation Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Lena J. Heung,

Affiliation Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
⨯
Debra K. Kumasaka,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Sue E. Knoblaugh,

Affiliation Comparative Medicine Shared Resources, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Xin Lin,

Affiliation Department of Molecular and Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Barbara I. Kazmierczak,

Affiliation Department of Medicine and Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Todd A. Reinhart,

Affiliation Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Robert A. Cramer,

Affiliation Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth University, Hanover, New Hampshire, United States of America
⨯
Tobias M. Hohl

* E-mail: hohlt@mskcc.org

Affiliations Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, Immunology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
⨯

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

Anupam Jhingran,
Shinji Kasahara,
Kelly M. Shepardson,
Beth A. Fallert Junecko,
Lena J. Heung,
Debra K. Kumasaka,
Sue E. Knoblaugh,
Xin Lin,
Barbara I. Kazmierczak,
Todd A. Reinhart

Published: January 26, 2015
https://doi.org/10.1371/journal.ppat.1004589

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Aspergillus fumigatus
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Immune receptor signaling
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