Chronic Parasitic Infection Maintains High Frequencies of Short-Lived Ly6C+CD4+ Effector T Cells That Are Required for Protection against Re-infection

Nathan C. Peters; Antonio J. Pagán; Phillip G. Lawyer; Timothy W. Hand; Eric Henrique Roma; Lisa W. Stamper; Audrey Romano; David L. Sacks

doi:10.1371/journal.ppat.1004538

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Open Access

Peer-reviewed

Research Article

Chronic Parasitic Infection Maintains High Frequencies of Short-Lived Ly6C⁺CD4⁺ Effector T Cells That Are Required for Protection against Re-infection

Nathan C. Peters ,

* E-mail: ncpeters@ucalgary.ca

Current address: Department of Microbiology Immunology and Infectious Diseases, Cumming School of Medicine, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

Affiliation Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Antonio J. Pagán,

Current address: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

Affiliation Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
⨯
Phillip G. Lawyer,

Affiliation Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Timothy W. Hand,

Affiliation Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Eric Henrique Roma,

Affiliation Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Lisa W. Stamper,

Affiliation Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Audrey Romano,

Affiliation Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
David L. Sacks

Affiliation Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Chronic Parasitic Infection Maintains High Frequencies of Short-Lived Ly6C⁺CD4⁺ Effector T Cells That Are Required for Protection against Re-infection

Nathan C. Peters,
Antonio J. Pagán,
Phillip G. Lawyer,
Timothy W. Hand,
Eric Henrique Roma,
Lisa W. Stamper,
Audrey Romano,
David L. Sacks

Published: December 4, 2014
https://doi.org/10.1371/journal.ppat.1004538

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