A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection

• Christopher E. Andoniou,

  Affiliations Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Western Australia, Australia, Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia

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• Vivien R. Sutton,

  Affiliations Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia

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• Matthew E. Wikstrom,

  Affiliations Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Western Australia, Australia, Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia

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• Peter Fleming,

  Affiliations Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Western Australia, Australia, Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia

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• Kevin Y. T. Thia,

  Affiliations Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia

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• Antony Y. Matthews,

  Affiliation Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

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• Dion Kaiserman,

  Affiliation Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

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• Iona S. Schuster,

  Affiliations Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Western Australia, Australia, Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia

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• Jerome D. Coudert,

  Affiliations Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Western Australia, Australia, Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia

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• Preethi Eldi,

  Affiliation Infection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia

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• Geeta Chaudhri,

  Affiliation Infection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia

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• Gunasegaran Karupiah,

  Affiliation Infection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia

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• Phillip I. Bird,

  Affiliation Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

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• Joseph A. Trapani ,

  Contributed equally to this work with: Joseph A. Trapani, Mariapia A. Degli-Esposti

  Affiliations Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia

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• Mariapia A. Degli-Esposti

  Contributed equally to this work with: Joseph A. Trapani, Mariapia A. Degli-Esposti

  * E-mail: mariapia@cyllene.uwa.edu.au

  Affiliations Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Western Australia, Australia, Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia

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