Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

Qing Yao; Li Zhang; Xiaobo Wan; Jing Chen; Liyan Hu; Xiaojun Ding; Lin Li; Jayashree Karar; Hongzhuang Peng; She Chen; Niu Huang; Frank J. Rauscher III; Feng Shao

doi:10.1371/journal.ppat.1004522

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Open Access

Peer-reviewed

Research Article

Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

Qing Yao ,

Contributed equally to this work with: Qing Yao, Li Zhang

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Li Zhang ,

Contributed equally to this work with: Qing Yao, Li Zhang

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Xiaobo Wan,

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Jing Chen,

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Liyan Hu,

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Xiaojun Ding,

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Lin Li,

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Jayashree Karar,

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Hongzhuang Peng,

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
She Chen,

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Niu Huang,

Affiliation National Institute of Biological Sciences, Beijing, China
⨯
Frank J. Rauscher III,

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Feng Shao

* E-mail: shaofeng@nibs.ac.cn

Affiliations National Institute of Biological Sciences, Beijing, China, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, National Institute of Biological Sciences, Beijing, Collaborative Innovation Center for Cancer Medicine, Beijing, China
⨯

Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

Qing Yao,
Li Zhang,
Xiaobo Wan,
Jing Chen,
Liyan Hu,
Xiaojun Ding,
Lin Li,
Jayashree Karar,
Hongzhuang Peng,
She Chen

Published: November 20, 2014
https://doi.org/10.1371/journal.ppat.1004522

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Methylation
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Cysteine
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Methyltransferases
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293T cells
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Biochemical simulations
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