IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications

Karen E. Johnson; Virginie Bottero; Stephanie Flaherty; Sujoy Dutta; Vivek Vikram Singh; Bala Chandran

doi:10.1371/journal.ppat.1004503

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Peer-reviewed

Research Article

IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications

Karen E. Johnson,

Affiliation H.M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Virginie Bottero,

Affiliation H.M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Stephanie Flaherty,

Affiliation H.M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Sujoy Dutta,

Affiliation H.M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Vivek Vikram Singh,

Affiliation H.M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Bala Chandran

* E-mail: Bala.chandran@rosalindfranklin.edu

Affiliation H.M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯

IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications

Karen E. Johnson,
Virginie Bottero,
Stephanie Flaherty,
Sujoy Dutta,
Vivek Vikram Singh,
Bala Chandran

Published: November 6, 2014
https://doi.org/10.1371/journal.ppat.1004503

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Gene expression
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Herpes simplex virus-1
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Viral replication
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Cloning
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Immunoprecipitation
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DNA replication
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