Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

Christine Burkard; Monique H. Verheije; Oliver Wicht; Sander I. van Kasteren; Frank J. van Kuppeveld; Bart L. Haagmans; Lucas Pelkmans; Peter J. M. Rottier; Berend Jan Bosch; Cornelis A. M. de Haan

doi:10.1371/journal.ppat.1004502

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Open Access

Peer-reviewed

Research Article

Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

Christine Burkard,

Current address: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, United Kingdom,

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Monique H. Verheije,

Current address: Department of Pathobiology, Division Pathology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Oliver Wicht,

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Sander I. van Kasteren,

Affiliation Division of Bio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
⨯
Frank J. van Kuppeveld,

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Bart L. Haagmans,

Affiliation Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
⨯
Lucas Pelkmans,

Affiliation Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
⨯
Peter J. M. Rottier,

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Berend Jan Bosch,

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Cornelis A. M. de Haan

* E-mail: c.a.m.dehaan@uu.nl

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯

Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

Christine Burkard,
Monique H. Verheije,
Oliver Wicht,
Sander I. van Kasteren,
Frank J. van Kuppeveld,
Bart L. Haagmans,
Lucas Pelkmans,
Peter J. M. Rottier,
Berend Jan Bosch,
Cornelis A. M. de Haan

Published: November 6, 2014
https://doi.org/10.1371/journal.ppat.1004502

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Cell fusion
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Lysosomes
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Small interfering RNA
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Endosomes
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