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Open Access
Peer-reviewed
Research Article
Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer
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Kathrin Buffen,
Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
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Marije Oosting,
Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
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Jessica Quintin,
Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
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Aylwin Ng,
Affiliations The Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America, Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Johanneke Kleinnijenhuis,
Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
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Vinod Kumar,
Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands
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Esther van de Vosse,
Affiliation Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
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Cisca Wijmenga,
Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands
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Reinout van Crevel,
Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
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Egbert Oosterwijk,
Affiliation Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands
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Anne J. Grotenhuis,
Affiliations Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands
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Sita H. Vermeulen,
Affiliations Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands, Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands
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Lambertus A. Kiemeney,
Affiliations Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands
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Frank L. van de Veerdonk,
Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
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Georgios Chamilos,
Affiliation Department of Medicine, University of Crete, Heraklion, Crete, Greece
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Ramnik J. Xavier,
Affiliations The Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America, Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Jos W. M. van der Meer,
Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
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Mihai G. Netea,
Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
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Leo A. B. Joosten
* E-mail: leo.joosten@radboudumc.nl
Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
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Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer
- Kathrin Buffen,
- Marije Oosting,
- Jessica Quintin,
- Aylwin Ng,
- Johanneke Kleinnijenhuis,
- Vinod Kumar,
- Esther van de Vosse,
- Cisca Wijmenga,
- Reinout van Crevel,
- Egbert Oosterwijk
- Published: October 30, 2014
- https://doi.org/10.1371/journal.ppat.1004485