One Small Step for a Yeast - Microevolution within Macrophages Renders Candida glabrata Hypervirulent Due to a Single Point Mutation

• Sascha Brunke ,

  Contributed equally to this work with: Sascha Brunke, Katja Seider

  Affiliations Integrated Research and Treatment Center, Sepsis und Sepsisfolgen, Center for Sepsis Control and Care (CSCC), Universitätsklinikum Jena, Jena, Germany, Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute Jena (HKI), Jena, Germany

  ⨯
• Katja Seider ,

  Contributed equally to this work with: Sascha Brunke, Katja Seider

  Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute Jena (HKI), Jena, Germany

  ⨯
• Daniel Fischer,

  Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute Jena (HKI), Jena, Germany

  ⨯
• Ilse D. Jacobsen,

  Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute Jena (HKI), Jena, Germany

  ⨯
• Lydia Kasper,

  Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute Jena (HKI), Jena, Germany

  ⨯
• Nadja Jablonowski,

  Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute Jena (HKI), Jena, Germany

  ⨯
• Anja Wartenberg,

  Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute Jena (HKI), Jena, Germany

  ⨯
• Oliver Bader,

  Affiliation Institute for Medical Microbiology and German National Reference Centre for Systemic Mycoses, University Medical Centre Göttingen, Göttingen, Germany

  ⨯
• Adela Enache-Angoulvant,

  Affiliation APHP, Hôpital Bicêtre, Service de Bactériologie-Virologie-Parasitologie, Laboratoire de Parasitologie-Mycologie, Kremlin-Bicêtre, France

  ⨯
• Martin Schaller,

  Affiliation Department of Dermatology, Eberhard-Karls-University, Tübingen, Germany

  ⨯
• Christophe d'Enfert,

  Affiliations Institut Pasteur, Unité Biologie et Pathogénicité Fongiques, Département Génomes et Génétique, Paris, France, INRA, USC2019, Paris, France

  ⨯
• Bernhard Hube

  * E-mail: bernhard.hube@hki-jena.de

  Affiliations Integrated Research and Treatment Center, Sepsis und Sepsisfolgen, Center for Sepsis Control and Care (CSCC), Universitätsklinikum Jena, Jena, Germany, Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute Jena (HKI), Jena, Germany, Friedrich Schiller University, Jena, Germany

  ⨯