Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

Amanda J. Price; David A. Jacques; William A. McEwan; Adam J. Fletcher; Sebastian Essig; Jason W. Chin; Upul D. Halambage; Christopher Aiken; Leo C. James

doi:10.1371/journal.ppat.1004459

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Open Access

Peer-reviewed

Research Article

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

Amanda J. Price ,

Contributed equally to this work with: Amanda J. Price, David A. Jacques

Affiliation Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom
⨯
David A. Jacques ,

Contributed equally to this work with: Amanda J. Price, David A. Jacques

Affiliation Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom
⨯
William A. McEwan,

Affiliation Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom
⨯
Adam J. Fletcher,

Affiliation Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom
⨯
Sebastian Essig,

Affiliation Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom
⨯
Jason W. Chin,

Affiliation Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom
⨯
Upul D. Halambage,

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Christopher Aiken,

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Leo C. James

* E-mail: lcj@mrc-lmb.cam.ac.uk

Affiliation Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom
⨯

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

Amanda J. Price,
David A. Jacques,
William A. McEwan,
Adam J. Fletcher,
Sebastian Essig,
Jason W. Chin,
Upul D. Halambage,
Christopher Aiken,
Leo C. James

Published: October 30, 2014
https://doi.org/10.1371/journal.ppat.1004459

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