Live Attenuated Francisella novicida Vaccine Protects against Francisella tularensis Pulmonary Challenge in Rats and Non-human Primates

Ping Chu; Aimee L. Cunningham; Jieh-Juen Yu; Jesse Q. Nguyen; Jeffrey R. Barker; C. Rick Lyons; Julie Wilder; Michelle Valderas; Robert L. Sherwood; Bernard P. Arulanandam; Karl E. Klose

doi:10.1371/journal.ppat.1004439

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Peer-reviewed

Research Article

Live Attenuated Francisella novicida Vaccine Protects against Francisella tularensis Pulmonary Challenge in Rats and Non-human Primates

Ping Chu,

Affiliation South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas San Antonio, San Antonio, Texas, United States of America
⨯
Aimee L. Cunningham,

Affiliation South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas San Antonio, San Antonio, Texas, United States of America
⨯
Jieh-Juen Yu,

Affiliation South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas San Antonio, San Antonio, Texas, United States of America
⨯
Jesse Q. Nguyen,

Affiliation South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas San Antonio, San Antonio, Texas, United States of America
⨯
Jeffrey R. Barker,

Affiliation South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas San Antonio, San Antonio, Texas, United States of America
⨯
C. Rick Lyons,

Affiliation Infectious Disease Research Center, Colorado State University, Fort Collins, Colorado, United States of America
⨯
Julie Wilder,

Affiliation Applied Life Sciences & Toxicology, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America
⨯
Michelle Valderas,

Affiliation Applied Life Sciences & Toxicology, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America
⨯
Robert L. Sherwood,

Affiliation Applied Life Sciences & Toxicology, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America
⨯
Bernard P. Arulanandam,

Affiliation South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas San Antonio, San Antonio, Texas, United States of America
⨯
Karl E. Klose

* E-mail: Karl.Klose@utsa.edu

Affiliation South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas San Antonio, San Antonio, Texas, United States of America
⨯

Live Attenuated Francisella novicida Vaccine Protects against Francisella tularensis Pulmonary Challenge in Rats and Non-human Primates

Ping Chu,
Aimee L. Cunningham,
Jieh-Juen Yu,
Jesse Q. Nguyen,
Jeffrey R. Barker,
C. Rick Lyons,
Julie Wilder,
Michelle Valderas,
Robert L. Sherwood,
Bernard P. Arulanandam

Published: October 23, 2014
https://doi.org/10.1371/journal.ppat.1004439

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Vaccination and immunization
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Francisella tularensis
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