Epstein-Barr Virus Nuclear Antigen 3A Promotes Cellular Proliferation by Repression of the Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1

Melissa L. Tursiella; Emily R. Bowman; Keith C. Wanzeck; Robert E. Throm; Jason Liao; Junjia Zhu; Clare E. Sample

doi:10.1371/journal.ppat.1004415

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Peer-reviewed

Research Article

Epstein-Barr Virus Nuclear Antigen 3A Promotes Cellular Proliferation by Repression of the Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1

Melissa L. Tursiella,

Affiliation Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, and the Penn State Hershey Cancer Institute, Hershey, Pennsylvania, United States of America
⨯
Emily R. Bowman,

Affiliation Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, and the Penn State Hershey Cancer Institute, Hershey, Pennsylvania, United States of America
⨯
Keith C. Wanzeck,

Current address: Department of Medicine, Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Affiliation Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Robert E. Throm,

Current address: Department of Experimental Hematology, Division of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Affiliation Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Jason Liao,

Affiliation Department of Public Health Sciences, Pennsylvania State University College of Medicine, and the Penn State Hershey Cancer Institute, Hershey, Pennsylvania, United States of America
⨯
Junjia Zhu,

Affiliation Department of Public Health Sciences, Pennsylvania State University College of Medicine, and the Penn State Hershey Cancer Institute, Hershey, Pennsylvania, United States of America
⨯
Clare E. Sample

* E-mail: csample@hmc.psu.edu

Affiliation Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, and the Penn State Hershey Cancer Institute, Hershey, Pennsylvania, United States of America
⨯

Epstein-Barr Virus Nuclear Antigen 3A Promotes Cellular Proliferation by Repression of the Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1

Melissa L. Tursiella,
Emily R. Bowman,
Keith C. Wanzeck,
Robert E. Throm,
Jason Liao,
Junjia Zhu,
Clare E. Sample

Published: October 2, 2014
https://doi.org/10.1371/journal.ppat.1004415

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Transfection
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Apoptosis
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Cancers and neoplasms
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Cyclins
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Immunoblotting
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Cell cycle and cell division
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Viral persistence and latency
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