Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by a Neutralizing Human Antibody

Open Access

Peer-reviewed

Research Article

Nadja Spindler ,

Contributed equally to this work with: Nadja Spindler, Uschi Diestel

Affiliation Institut für Klinische und Molekulare Virologie, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
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Uschi Diestel ,

Contributed equally to this work with: Nadja Spindler, Uschi Diestel

Affiliation Lehrstuhl für Biotechnik, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Joachim D. Stump,

Affiliation Institut für Biochemie, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
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Anna-Katharina Wiegers,

Affiliation Institut für Klinische und Molekulare Virologie, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
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Thomas H. Winkler,

Affiliation Nikolaus-Fiebiger-Zentrum für Molekulare Medizin, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
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Heinrich Sticht,

Affiliation Institut für Biochemie, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
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Michael Mach ,

* E-mail: michael.mach@fau.de. (MM); yves.muller@fau.de. (YAM)

Affiliation Institut für Klinische und Molekulare Virologie, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
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Yves A. Muller

* E-mail: michael.mach@fau.de. (MM); yves.muller@fau.de. (YAM)

Affiliation Lehrstuhl für Biotechnik, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
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Crystal structure
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Antibodies
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Antigens
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Human cytomegalovirus
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Hydrogen bonding
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Membrane fusion
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Molecular dynamics
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Biochemical simulations
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