Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

Kevin M. Vannella; Luke Barron; Lee A. Borthwick; Kristen N. Kindrachuk; Prakash Babu Narasimhan; Kevin M. Hart; Robert W. Thompson; Sandra White; Allen W. Cheever; Thirumalai R. Ramalingam; Thomas A. Wynn

doi:10.1371/journal.ppat.1004372

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Open Access

Peer-reviewed

Research Article

Incomplete Deletion of IL-4Rα by LysM^Cre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

Kevin M. Vannella,

Affiliation Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Luke Barron,

Affiliation Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Lee A. Borthwick,

Affiliations Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Kristen N. Kindrachuk,

Affiliation Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Prakash Babu Narasimhan,

Affiliation Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Kevin M. Hart,

Affiliation Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Robert W. Thompson,

Affiliation Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Sandra White,

Affiliation Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Allen W. Cheever,

Affiliation Biomedical Research Institute, Rockville, Maryland, United States of America
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Thirumalai R. Ramalingam,

Affiliation Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Thomas A. Wynn

* E-mail: twynn@niaid.nih.gov

Affiliation Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Incomplete Deletion of IL-4Rα by LysM^Cre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

Kevin M. Vannella,
Luke Barron,
Lee A. Borthwick,
Kristen N. Kindrachuk,
Prakash Babu Narasimhan,
Kevin M. Hart,
Robert W. Thompson,
Sandra White,
Allen W. Cheever,
Thirumalai R. Ramalingam

Published: September 11, 2014
https://doi.org/10.1371/journal.ppat.1004372

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Macrophages
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Fibrosis
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Schistosoma mansoni
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Gene expression
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Eggs
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