RC1339/APRc from Rickettsia conorii Is a Novel Aspartic Protease with Properties of Retropepsin-Like Enzymes

• Rui Cruz,

  Affiliations The Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal, Biocant, Biotechnology Innovation Center, Cantanhede, Portugal

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• Pitter Huesgen,

  Affiliation Centre for Blood Research and Department of Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada

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• Sean P. Riley,

  Affiliation Vector-Borne Diseases Laboratories, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America

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• Alexander Wlodawer,

  Affiliation Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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• Carlos Faro,

  Affiliations The Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal, Biocant, Biotechnology Innovation Center, Cantanhede, Portugal

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• Christopher M. Overall,

  Affiliations Centre for Blood Research and Department of Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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• Juan J. Martinez ,

  * E-mail: jmartinez@lsu.edu (JJM); isimoes@biocant.pt (IS)

  Affiliation Vector-Borne Diseases Laboratories, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America

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• Isaura Simões

  * E-mail: jmartinez@lsu.edu (JJM); isimoes@biocant.pt (IS)

  Affiliations The Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal, Biocant, Biotechnology Innovation Center, Cantanhede, Portugal

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