Production of an Attenuated Phenol-Soluble Modulin Variant Unique to the MRSA Clonal Complex 30 Increases Severity of Bloodstream Infection

Gordon Y. C. Cheung; Dorothee Kretschmer; Anthony C. Duong; Anthony J. Yeh; Trung V. Ho; Yan Chen; Hwang-Soo Joo; Barry N. Kreiswirth; Andreas Peschel; Michael Otto

doi:10.1371/journal.ppat.1004298

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Open Access

Peer-reviewed

Research Article

Production of an Attenuated Phenol-Soluble Modulin Variant Unique to the MRSA Clonal Complex 30 Increases Severity of Bloodstream Infection

Gordon Y. C. Cheung,

Affiliation Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Dorothee Kretschmer,

Affiliation Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany
⨯
Anthony C. Duong,

Affiliation Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Anthony J. Yeh,

Affiliation Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Trung V. Ho,

Affiliation Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yan Chen,

Affiliation Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Hwang-Soo Joo,

Affiliation Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Barry N. Kreiswirth,

Affiliation Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Andreas Peschel,

Affiliation Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany
⨯
Michael Otto

* E-mail: motto@niaid.nih.gov

Affiliation Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Production of an Attenuated Phenol-Soluble Modulin Variant Unique to the MRSA Clonal Complex 30 Increases Severity of Bloodstream Infection

Gordon Y. C. Cheung,
Dorothee Kretschmer,
Anthony C. Duong,
Anthony J. Yeh,
Trung V. Ho,
Yan Chen,
Hwang-Soo Joo,
Barry N. Kreiswirth,
Andreas Peschel,
Michael Otto

Published: August 21, 2014
https://doi.org/10.1371/journal.ppat.1004298

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