Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore

Anusha Panjwani; Mike Strauss; Sarah Gold; Hannah Wenham; Terry Jackson; James J. Chou; David J. Rowlands; Nicola J. Stonehouse; James M. Hogle; Tobias J. Tuthill

doi:10.1371/journal.ppat.1004294

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Peer-reviewed

Research Article

Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore

Anusha Panjwani,

Affiliations The Pirbright Institute, Pirbright, Surrey, United Kingdom, School of Molecular and Cellular Biology & Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, West Yorkshire, United Kingdom
⨯
Mike Strauss,

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Sarah Gold,

Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom
⨯
Hannah Wenham,

Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom
⨯
Terry Jackson,

Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom
⨯
James J. Chou,

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
David J. Rowlands,

Affiliation School of Molecular and Cellular Biology & Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, West Yorkshire, United Kingdom
⨯
Nicola J. Stonehouse,

Affiliation School of Molecular and Cellular Biology & Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, West Yorkshire, United Kingdom
⨯
James M. Hogle,

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Tobias J. Tuthill

* E-mail: toby.tuthill@pirbright.ac.uk

Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom
⨯

Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore

Anusha Panjwani,
Mike Strauss,
Sarah Gold,
Hannah Wenham,
Terry Jackson,
James J. Chou,
David J. Rowlands,
Nicola J. Stonehouse,
James M. Hogle,
Tobias J. Tuthill

Published: August 7, 2014
https://doi.org/10.1371/journal.ppat.1004294

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