BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

• Rebecca D. Oppenheim,

  Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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• Darren J. Creek ,

  Contributed equally to this work with: Darren J. Creek, James I. Macrae, Katarzyna K. Modrzynska, Paco Pino

  Affiliations Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia, Wellcome Trust Centre for Molecular Parasitology and Glasgow Polyomics, University of Glasgow, Glasgow, United Kingdom, Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

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• James I. Macrae ,

  Contributed equally to this work with: Darren J. Creek, James I. Macrae, Katarzyna K. Modrzynska, Paco Pino

  Affiliations Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia, The National Institute for Medical Research, Mill Hill, London, United Kingdom

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• Katarzyna K. Modrzynska ,

  Contributed equally to this work with: Darren J. Creek, James I. Macrae, Katarzyna K. Modrzynska, Paco Pino

  Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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• Paco Pino ,

  Contributed equally to this work with: Darren J. Creek, James I. Macrae, Katarzyna K. Modrzynska, Paco Pino

  Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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• Julien Limenitakis,

  Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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• Valerie Polonais,

  Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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• Frank Seeber,

  Affiliation FG16 - Mycotic and parasitic agents and mycobacteria, Robert Koch Institute, Berlin, Germany

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• Michael P. Barrett,

  Affiliation Wellcome Trust Centre for Molecular Parasitology and Glasgow Polyomics, University of Glasgow, Glasgow, United Kingdom

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• Oliver Billker,

  Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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• Malcolm J. McConville,

  Affiliation Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia

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• Dominique Soldati-Favre

  * E-mail: Dominique.Soldati-Favre@unige.ch

  Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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