T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

Marcus Buggert; Johanna Tauriainen; Takuya Yamamoto; Juliet Frederiksen; Martin A. Ivarsson; Jakob Michaëlsson; Ole Lund; Bo Hejdeman; Marianne Jansson; Anders Sönnerborg; Richard A. Koup; Michael R. Betts; Annika C. Karlsson

doi:10.1371/journal.ppat.1004251

Loading metrics

Open Access

Peer-reviewed

Research Article

T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

Marcus Buggert ,

* E-mail: marcus.buggert@ki.se

Affiliation Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Johanna Tauriainen,

Affiliation Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Takuya Yamamoto,

Affiliation Immunology Laboratory, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Juliet Frederiksen,

Affiliation Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
⨯
Martin A. Ivarsson,

Affiliation Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
⨯
Jakob Michaëlsson,

Affiliation Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
⨯
Ole Lund,

Affiliation Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
⨯
Bo Hejdeman,

Affiliation Department of Infectious Diseases Venhälsan, Stockholm South General Hospital (Södersjukhuset), Stockholm, Sweden
⨯
Marianne Jansson,

Affiliations Department of Laboratory Medicine, Lund University, Lund, Sweden, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Anders Sönnerborg,

Affiliations Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Richard A. Koup,

Affiliation Immunology Laboratory, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Michael R. Betts,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Annika C. Karlsson

Affiliation Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
⨯

T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

Marcus Buggert,
Johanna Tauriainen,
Takuya Yamamoto,
Juliet Frederiksen,
Martin A. Ivarsson,
Jakob Michaëlsson,
Ole Lund,
Bo Hejdeman,
Marianne Jansson,
Anders Sönnerborg

Published: July 17, 2014
https://doi.org/10.1371/journal.ppat.1004251

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
HIV infections
Is the Subject Area "HIV infections" applicable to this article?

Thanks for your feedback.
CD coreceptors
Is the Subject Area "CD coreceptors" applicable to this article?

Thanks for your feedback.
T cell receptors
Is the Subject Area "T cell receptors" applicable to this article?

Thanks for your feedback.
Virus testing
Is the Subject Area "Virus testing" applicable to this article?

Thanks for your feedback.
Cloning
Is the Subject Area "Cloning" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.