Structure of the Trehalose-6-phosphate Phosphatase from Brugia malayi Reveals Key Design Principles for Anthelmintic Drugs

Jeremiah D. Farelli; Brendan D. Galvin; Zhiru Li; Chunliang Liu; Miyuki Aono; Megan Garland; Olivia E. Hallett; Thomas B. Causey; Alana Ali-Reynolds; Daniel J. Saltzberg; Clotilde K. S. Carlow; Debra Dunaway-Mariano; Karen N. Allen

doi:10.1371/journal.ppat.1004245

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Open Access

Peer-reviewed

Research Article

Structure of the Trehalose-6-phosphate Phosphatase from Brugia malayi Reveals Key Design Principles for Anthelmintic Drugs

Jeremiah D. Farelli,

Affiliation Department of Chemistry, Boston University, Boston, Massachusetts, United States of America
⨯
Brendan D. Galvin,

Affiliation New England Biolabs, Division of Parasitology, Ipswich, Massachusetts, United States of America
⨯
Zhiru Li,

Affiliation New England Biolabs, Division of Parasitology, Ipswich, Massachusetts, United States of America
⨯
Chunliang Liu,

Affiliation Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico, United States of America
⨯
Miyuki Aono,

Affiliation Department of Chemistry, Boston University, Boston, Massachusetts, United States of America
⨯
Megan Garland,

Affiliation Department of Chemistry, Boston University, Boston, Massachusetts, United States of America
⨯
Olivia E. Hallett,

Affiliation Department of Chemistry, Boston University, Boston, Massachusetts, United States of America
⨯
Thomas B. Causey,

Affiliation New England Biolabs, Division of Parasitology, Ipswich, Massachusetts, United States of America
⨯
Alana Ali-Reynolds,

Affiliation New England Biolabs, Division of Parasitology, Ipswich, Massachusetts, United States of America
⨯
Daniel J. Saltzberg,

Affiliation Department of Chemistry, Boston University, Boston, Massachusetts, United States of America
⨯
Clotilde K. S. Carlow,

Affiliation New England Biolabs, Division of Parasitology, Ipswich, Massachusetts, United States of America
⨯
Debra Dunaway-Mariano ,

* E-mail: dd39@unm.edu (DDM); drkallen@bu.edu (KNA)

Affiliation Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico, United States of America
⨯
Karen N. Allen

* E-mail: dd39@unm.edu (DDM); drkallen@bu.edu (KNA)

Affiliation Department of Chemistry, Boston University, Boston, Massachusetts, United States of America
⨯

Structure of the Trehalose-6-phosphate Phosphatase from Brugia malayi Reveals Key Design Principles for Anthelmintic Drugs

Jeremiah D. Farelli,
Brendan D. Galvin,
Zhiru Li,
Chunliang Liu,
Miyuki Aono,
Megan Garland,
Olivia E. Hallett,
Thomas B. Causey,
Alana Ali-Reynolds,
Daniel J. Saltzberg

Published: July 3, 2014
https://doi.org/10.1371/journal.ppat.1004245

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