Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins

Lisheng Peng; Michael Adler; Ann Demogines; Andrew Borrell; Huisheng Liu; Liang Tao; William H. Tepp; Su-Chun Zhang; Eric A. Johnson; Sara L. Sawyer; Min Dong

doi:10.1371/journal.ppat.1004177

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Peer-reviewed

Research Article

Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins

Lisheng Peng,

Affiliation Department of Microbiology and Immunobiology, Harvard Medical School and Division of Neuroscience, New England Primate Research Center, Southborough, Massachusetts, United States of America
⨯
Michael Adler ,

* E-mail: michael.adler2.civ@mail.mil (MA); saras@austin.utexas.edu (SLS); min_dong@hms.harvard.edu (MD)

Affiliation Neurobehavioral Toxicology Branch, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Aberdeen, Maryland, United States of America
⨯
Ann Demogines,

Affiliation Department of Molecular Biosciences, University of Texas, Austin, Texas, United States of America
⨯
Andrew Borrell,

Affiliation Neurobehavioral Toxicology Branch, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Aberdeen, Maryland, United States of America
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Huisheng Liu,

Affiliation Waisman Center, Department of Neuroscience, Department of Neurology, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Liang Tao,

Affiliation Department of Microbiology and Immunobiology, Harvard Medical School and Division of Neuroscience, New England Primate Research Center, Southborough, Massachusetts, United States of America
⨯
William H. Tepp,

Affiliation Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America
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Su-Chun Zhang,

Affiliation Waisman Center, Department of Neuroscience, Department of Neurology, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Eric A. Johnson,

Affiliation Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Sara L. Sawyer ,

* E-mail: michael.adler2.civ@mail.mil (MA); saras@austin.utexas.edu (SLS); min_dong@hms.harvard.edu (MD)

Affiliation Department of Molecular Biosciences, University of Texas, Austin, Texas, United States of America
⨯
Min Dong

* E-mail: michael.adler2.civ@mail.mil (MA); saras@austin.utexas.edu (SLS); min_dong@hms.harvard.edu (MD)

Affiliation Department of Microbiology and Immunobiology, Harvard Medical School and Division of Neuroscience, New England Primate Research Center, Southborough, Massachusetts, United States of America
⨯

Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins

Lisheng Peng,
Michael Adler,
Ann Demogines,
Andrew Borrell,
Huisheng Liu,
Liang Tao,
William H. Tepp,
Su-Chun Zhang,
Eric A. Johnson,
Sara L. Sawyer

Published: July 10, 2014
https://doi.org/10.1371/journal.ppat.1004177

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23 Sep 2014
13:58 GMT
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The main sites of action of botulinum neurotoxins in animals Posted by ornellarossetto on 23 Sep 2014 at 13:58 GMT

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