Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus

• Anna Lundin ,

  Contributed equally to this work with: Anna Lundin, Ronald Dijkman

  Affiliation Department of Clinical Virology, University of Gothenburg, Göteborg, Sweden

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• Ronald Dijkman ,

  Contributed equally to this work with: Anna Lundin, Ronald Dijkman

  Affiliations Institute of Immunobiology, Kantonal Hospital St.Gallen, St.Gallen, Switzerland, Federal Department of Home Affairs, Institute of Virology and Immunology, Berne and Mittelhäusern, Switzerland

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• Tomas Bergström,

  Affiliation Department of Clinical Virology, University of Gothenburg, Göteborg, Sweden

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• Nina Kann,

  Affiliation Organic Chemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden

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• Beata Adamiak,

  Current address: Avian Viral Diseases Programme, The Pirbright Institute, Compton Laboratory, Compton, United Kingdom

  Affiliation Department of Clinical Virology, University of Gothenburg, Göteborg, Sweden

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• Charles Hannoun,

  Affiliation Department of Clinical Virology, University of Gothenburg, Göteborg, Sweden

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• Eveline Kindler,

  Affiliations Institute of Immunobiology, Kantonal Hospital St.Gallen, St.Gallen, Switzerland, Federal Department of Home Affairs, Institute of Virology and Immunology, Berne and Mittelhäusern, Switzerland

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• Hulda R. Jónsdóttir,

  Affiliations Institute of Immunobiology, Kantonal Hospital St.Gallen, St.Gallen, Switzerland, Federal Department of Home Affairs, Institute of Virology and Immunology, Berne and Mittelhäusern, Switzerland

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• Doreen Muth,

  Affiliation Institute of Virology, University of Bonn Medical Centre, Bonn, Germany

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• Joeri Kint,

  Affiliations Department of Animal Sciences, Cell Biology and Immunology Group, Wageningen Institute of Animal Sciences, Wageningen University, Wageningen, The Netherlands, Merck Animal Health, Bioprocess Technology & Support, Boxmeer, The Netherlands

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• Maria Forlenza,

  Affiliation Department of Animal Sciences, Cell Biology and Immunology Group, Wageningen Institute of Animal Sciences, Wageningen University, Wageningen, The Netherlands

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• Marcel A. Müller,

  Affiliation Institute of Virology, University of Bonn Medical Centre, Bonn, Germany

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• Christian Drosten,

  Affiliation Institute of Virology, University of Bonn Medical Centre, Bonn, Germany

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• Volker Thiel ,

  * E-mail: volker.thiel@vetsuisse.unibe.ch (VT); eward.trybala@microbio.gu.se (ET)

  Affiliations Institute of Immunobiology, Kantonal Hospital St.Gallen, St.Gallen, Switzerland, Federal Department of Home Affairs, Institute of Virology and Immunology, Berne and Mittelhäusern, Switzerland, Vetsuisse Faculty, University of Berne, Berne, Switzerland

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• Edward Trybala

  * E-mail: volker.thiel@vetsuisse.unibe.ch (VT); eward.trybala@microbio.gu.se (ET)

  Affiliation Department of Clinical Virology, University of Gothenburg, Göteborg, Sweden

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