Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis

Amelia K. Pinto; Hilario J. Ramos; Xiaobo Wu; Shilpa Aggarwal; Bimmi Shrestha; Matthew Gorman; Kristin Y. Kim; Mehul S. Suthar; John P. Atkinson; Michael Gale Jr; Michael S. Diamond

doi:10.1371/journal.ppat.1004086

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Peer-reviewed

Research Article

Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis

Amelia K. Pinto,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Hilario J. Ramos,

Affiliation Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Xiaobo Wu,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Shilpa Aggarwal †,

† Deceased.

Affiliation Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Bimmi Shrestha,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Matthew Gorman,

Affiliation Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kristin Y. Kim,

Affiliation Department of Pediatrics, Emory Vaccine Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, United States of America
⨯
Mehul S. Suthar,

Affiliation Department of Pediatrics, Emory Vaccine Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, United States of America
⨯
John P. Atkinson,

Affiliations Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Michael Gale Jr,

Affiliation Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Michael S. Diamond

* E-mail: diamond@borcim.wustl.edu

Affiliations Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis

Amelia K. Pinto,
Hilario J. Ramos,
Xiaobo Wu,
Shilpa Aggarwal,
Bimmi Shrestha,
Matthew Gorman,
Kristin Y. Kim,
Mehul S. Suthar,
John P. Atkinson,
Michael Gale Jr

Published: April 17, 2014
https://doi.org/10.1371/journal.ppat.1004086

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