HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality

• Sergio Serrano-Villar ,

  * E-mail: serranovillar@gmail.com

  Affiliation Department of Infectious Diseases, University Hospital Ramón y Cajal, Madrid, Spain

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• Talia Sainz,

  Affiliation Molecular Immune Biology Laboratory, University Hospital Gregorio Marañón, Madrid, Spain

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• Sulggi A. Lee,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Peter W. Hunt,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Elizabeth Sinclair,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Barbara L. Shacklett,

  Affiliation Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America

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• April L. Ferre,

  Affiliation Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America

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• Timothy L. Hayes,

  Affiliation Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America

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• Ma Somsouk,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Priscilla Y. Hsue,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Mark L. Van Natta,

  Affiliation Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Curtis L. Meinert,

  Affiliation Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Michael M. Lederman,

  Affiliation Case Western Reserve University, Cleveland, Ohio, United States of America

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• Hiroyu Hatano,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Vivek Jain,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Yong Huang,

  Affiliation Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

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• Frederick M. Hecht,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Jeffrey N. Martin,

  Affiliation Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

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• Joseph M. McCune,

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• Santiago Moreno,

  Affiliation Department of Infectious Diseases, University Hospital Ramón y Cajal, Madrid, Spain

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•  [ ... ],
• Steven G. Deeks

  Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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