Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

Jose L. Nieto-Torres; Marta L. DeDiego; Carmina Verdiá-Báguena; Jose M. Jimenez-Guardeño; Jose A. Regla-Nava; Raul Fernandez-Delgado; Carlos Castaño-Rodriguez; Antonio Alcaraz; Jaume Torres; Vicente M. Aguilella; Luis Enjuanes

doi:10.1371/journal.ppat.1004077

Open Access

Peer-reviewed

Research Article

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

Jose L. Nieto-Torres,

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Marta L. DeDiego,

Current address: David H. Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Carmina Verdiá-Báguena,

Affiliation Department of Physics, Laboratory of Molecular Biophysics. Universitat Jaume I, Castellón, Spain
⨯
Jose M. Jimenez-Guardeño,

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Jose A. Regla-Nava,

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Raul Fernandez-Delgado,

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Carlos Castaño-Rodriguez,

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Antonio Alcaraz,

Affiliation Department of Physics, Laboratory of Molecular Biophysics. Universitat Jaume I, Castellón, Spain
⨯
Jaume Torres,

Affiliation School of Biological Sciences, Division of Structural and Computational Biology, Nanyang Technological University, Singapore, Singapore
⨯
Vicente M. Aguilella,

Affiliation Department of Physics, Laboratory of Molecular Biophysics. Universitat Jaume I, Castellón, Spain
⨯
Luis Enjuanes

* E-mail: L.Enjuanes@cnb.csic.es

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

Jose L. Nieto-Torres, …
Marta L. DeDiego,
Carmina Verdiá-Báguena,
Jose M. Jimenez-Guardeño,
Jose A. Regla-Nava,
Raul Fernandez-Delgado,
Carlos Castaño-Rodriguez,
Antonio Alcaraz,
Jaume Torres,
Vicente M. Aguilella

Published: May 1, 2014
https://doi.org/10.1371/journal.ppat.1004077

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