Potent Dengue Virus Neutralization by a Therapeutic Antibody with Low Monovalent Affinity Requires Bivalent Engagement

• Melissa A. Edeling,

  Affiliation Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• S. Kyle Austin,

  Affiliation Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Bimmi Shrestha,

  Affiliation Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Kimberly A. Dowd,

  Affiliation Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Swati Mukherjee,

  Affiliation Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Christopher A. Nelson,

  Affiliation Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Syd Johnson,

  Affiliation MacroGenics, Rockville, Maryland, United States of America

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• Manu N. Mabila,

  Affiliation Integral Molecular, Philadelphia, Pennsylvania, United States of America

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• Elizabeth A. Christian,

  Affiliation Integral Molecular, Philadelphia, Pennsylvania, United States of America

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• Joseph Rucker,

  Affiliation Integral Molecular, Philadelphia, Pennsylvania, United States of America

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• Theodore C. Pierson,

  Affiliation Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Michael S. Diamond,

  Affiliations Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Daved H. Fremont

  * E-mail: fremont@wustl.edu

  Affiliations Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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