Coxsackievirus-Induced miR-21 Disrupts Cardiomyocyte Interactions via the Downregulation of Intercalated Disk Components

Xin Ye; Huifang Mary Zhang; Ye Qiu; Paul J. Hanson; Maged Gomaa Hemida; Wei Wei; Pamela A. Hoodless; Fanny Chu; Decheng Yang

doi:10.1371/journal.ppat.1004070

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Open Access

Peer-reviewed

Research Article

Coxsackievirus-Induced miR-21 Disrupts Cardiomyocyte Interactions via the Downregulation of Intercalated Disk Components

Xin Ye,

Affiliation Department of Pathology and Laboratory Medicine, University of British Columbia, The Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada
⨯
Huifang Mary Zhang,

Affiliation Department of Pathology and Laboratory Medicine, University of British Columbia, The Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada
⨯
Ye Qiu,

Affiliation Department of Pathology and Laboratory Medicine, University of British Columbia, The Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada
⨯
Paul J. Hanson,

Affiliation Department of Pathology and Laboratory Medicine, University of British Columbia, The Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada
⨯
Maged Gomaa Hemida,

Affiliation Department of Pathology and Laboratory Medicine, University of British Columbia, The Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada
⨯
Wei Wei,

Affiliation Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Pamela A. Hoodless,

Affiliation Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Fanny Chu,

Affiliation Department of Pathology and Laboratory Medicine, University of British Columbia, The Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada
⨯
Decheng Yang

* E-mail: decheng.yang@hli.ubc.ca

Affiliation Department of Pathology and Laboratory Medicine, University of British Columbia, The Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada
⨯

Coxsackievirus-Induced miR-21 Disrupts Cardiomyocyte Interactions via the Downregulation of Intercalated Disk Components

Xin Ye,
Huifang Mary Zhang,
Ye Qiu,
Paul J. Hanson,
Maged Gomaa Hemida,
Wei Wei,
Pamela A. Hoodless,
Fanny Chu,
Decheng Yang

Published: April 10, 2014
https://doi.org/10.1371/journal.ppat.1004070

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