TCR Affinity Associated with Functional Differences between Dominant and Subdominant SIV Epitope-Specific CD8+ T Cells in Mamu-A*01+ Rhesus Monkeys

Christa E. Osuna; Ana Maria Gonzalez; Hsun-Hsien Chang; Amy Shi Hung; Elizabeth Ehlinger; Kara Anasti; S. Munir Alam; Norman L. Letvin

doi:10.1371/journal.ppat.1004069

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Peer-reviewed

Research Article

TCR Affinity Associated with Functional Differences between Dominant and Subdominant SIV Epitope-Specific CD8⁺ T Cells in Mamu-A01*⁺ Rhesus Monkeys

Christa E. Osuna ,

* E-mail: ceo009@mail.harvard.edu

Affiliations Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Ana Maria Gonzalez,

Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Hsun-Hsien Chang,

Affiliation Children's Hospital Informatics Program, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Amy Shi Hung,

Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Elizabeth Ehlinger,

Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kara Anasti,

Affiliation Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
S. Munir Alam,

Affiliations Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Pathology, Duke University of Medicine, Durham, North Carolina, United States of America
⨯
Norman L. Letvin

Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

TCR Affinity Associated with Functional Differences between Dominant and Subdominant SIV Epitope-Specific CD8⁺ T Cells in Mamu-A01*⁺ Rhesus Monkeys

Christa E. Osuna,
Ana Maria Gonzalez,
Hsun-Hsien Chang,
Amy Shi Hung,
Elizabeth Ehlinger,
Kara Anasti,
S. Munir Alam,
Norman L. Letvin

Published: April 17, 2014
https://doi.org/10.1371/journal.ppat.1004069

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