Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation

Jeanette Wagener; R. K. Subbarao Malireddi; Megan D. Lenardon; Martin Köberle; Simon Vautier; Donna M. MacCallum; Tilo Biedermann; Martin Schaller; Mihai G. Netea; Thirumala-Devi Kanneganti; Gordon D. Brown; Alistair J. P. Brown; Neil A. R. Gow

doi:10.1371/journal.ppat.1004050

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Open Access

Peer-reviewed

Research Article

Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation

Jeanette Wagener,

Affiliation Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
R. K. Subbarao Malireddi,

Affiliation Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Megan D. Lenardon,

Affiliation Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Martin Köberle,

Affiliation Department of Dermatology, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Simon Vautier,

Affiliation Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Donna M. MacCallum,

Affiliation Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Tilo Biedermann,

Affiliation Department of Dermatology, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Martin Schaller,

Affiliation Department of Dermatology, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Mihai G. Netea,

Affiliation Department of Internal Medicine and Nijmegen Institute for Infection, Inflammation & Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
⨯
Thirumala-Devi Kanneganti,

Affiliation Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Gordon D. Brown,

Affiliation Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Alistair J. P. Brown,

Affiliation Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Neil A. R. Gow

* E-mail: n.gow@abdn.ac.uk

Affiliation Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯

Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation

Jeanette Wagener,
R. K. Subbarao Malireddi,
Megan D. Lenardon,
Martin Köberle,
Simon Vautier,
Donna M. MacCallum,
Tilo Biedermann,
Martin Schaller,
Mihai G. Netea,
Thirumala-Devi Kanneganti

Published: April 10, 2014
https://doi.org/10.1371/journal.ppat.1004050

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Chitin
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Secretion
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Candida albicans
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Cell walls
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