First Experimental In Vivo Model of Enhanced Dengue Disease Severity through Maternally Acquired Heterotypic Dengue Antibodies

Jowin Kai Wei Ng; Summer Lixin Zhang; Hwee Cheng Tan; Benedict Yan; Julia Maria Martinez Gomez; Wei Yu Tan; Jian Hang Lam; Grace Kai Xin Tan; Eng Eong Ooi; Sylvie Alonso

doi:10.1371/journal.ppat.1004031

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Open Access

Peer-reviewed

Research Article

First Experimental In Vivo Model of Enhanced Dengue Disease Severity through Maternally Acquired Heterotypic Dengue Antibodies

Jowin Kai Wei Ng,

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore
⨯
Summer Lixin Zhang,

Affiliation Defence Science Organization National Laboratories, Singapore
⨯
Hwee Cheng Tan,

Affiliation Progamme in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore
⨯
Benedict Yan,

Affiliation Department of Pathology, National University Health System and National University of Singapore, Singapore
⨯
Julia Maria Martinez Gomez,

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore
⨯
Wei Yu Tan,

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore
⨯
Jian Hang Lam,

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore
⨯
Grace Kai Xin Tan,

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore
⨯
Eng Eong Ooi,

Affiliation Progamme in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore
⨯
Sylvie Alonso

* E-mail: micas@nus.edu.sg

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore
⨯

First Experimental In Vivo Model of Enhanced Dengue Disease Severity through Maternally Acquired Heterotypic Dengue Antibodies

Jowin Kai Wei Ng,
Summer Lixin Zhang,
Hwee Cheng Tan,
Benedict Yan,
Julia Maria Martinez Gomez,
Wei Yu Tan,
Jian Hang Lam,
Grace Kai Xin Tan,
Eng Eong Ooi,
Sylvie Alonso

Published: April 3, 2014
https://doi.org/10.1371/journal.ppat.1004031

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