Adaptive Gene Amplification As an Intermediate Step in the Expansion of Virus Host Range

Open Access

Peer-reviewed

Research Article

Greg Brennan,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Jacob O. Kitzman,

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
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Stefan Rothenburg,

Affiliation Division of Biology, Kansas State University, Manhattan, Kansas, United States of America
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Jay Shendure,

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
⨯
Adam P. Geballe

* E-mail: ageballe@fhcrc.org

Affiliations Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Departments of Microbiology and Medicine, University of Washington, Seattle, Washington, United States of America
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Viral replication
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Vaccinia virus
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Gene pool
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Polymerase chain reaction
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Evolutionary adaptation
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Microbial mutation
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Phosphorylation
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Viral tropism
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