Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

• Niyas Kudukkil Pulloor,

  Affiliation Program on Emerging Infectious Diseases, DUKE-NUS Graduate Medical School, Singapore

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• Sajith Nair ,

  Contributed equally to this work with: Sajith Nair, Aleksandar D. Kostic

  Affiliation Program on Emerging Infectious Diseases, DUKE-NUS Graduate Medical School, Singapore

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• Aleksandar D. Kostic ,

  Contributed equally to this work with: Sajith Nair, Aleksandar D. Kostic

  Affiliation Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Pradeep Bist,

  Affiliation Program on Emerging Infectious Diseases, DUKE-NUS Graduate Medical School, Singapore

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• Jeremy D. Weaver,

  Affiliation Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina, United States of America

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• Andrew M. Riley,

  Affiliation Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, United Kingdom

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• Richa Tyagi,

  Affiliation Solomon H. Snyder Department of Neuroscience and Departments of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Pradeep D. Uchil,

  Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• John D. York,

  Affiliation Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Solomon H. Snyder,

  Affiliation Solomon H. Snyder Department of Neuroscience and Departments of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Adolfo García-Sastre,

  Affiliation Department of Microbiology, Global Health and Emerging Pathogens Institute, Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Barry V. L. Potter,

  Affiliation Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, United Kingdom

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• Rongtuan Lin,

  Affiliation Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada

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• Stephen B. Shears,

  Affiliation Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina, United States of America

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• Ramnik J. Xavier,

  Affiliation Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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•  [ ... ],
• Manoj N. Krishnan

  * E-mail: manoj.krishnan@duke-nus.edu.sg

  Affiliation Program on Emerging Infectious Diseases, DUKE-NUS Graduate Medical School, Singapore

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