In Vivo Administration of a JAK3 Inhibitor during Acute SIV Infection Leads to Significant Increases in Viral Load during Chronic Infection

Yoshiaki Takahashi; Siddappa N. Byrareddy; Christina Albrecht; Markus Brameier; Lutz Walter; Ann E. Mayne; Paul Dunbar; Robert Russo; Dawn M. Little; Tara Villinger; Ladawan Khowawisetsut; Kovit Pattanapanyasat; Francois Villinger; Aftab A. Ansari

doi:10.1371/journal.ppat.1003929

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Open Access

Peer-reviewed

Research Article

In Vivo Administration of a JAK3 Inhibitor during Acute SIV Infection Leads to Significant Increases in Viral Load during Chronic Infection

Yoshiaki Takahashi,

Current address: Laboratory of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Affiliation Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Siddappa N. Byrareddy,

Affiliation Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Christina Albrecht,

Affiliation Primate Genetics Laboratory, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany
⨯
Markus Brameier,

Affiliation Primate Genetics Laboratory, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany
⨯
Lutz Walter,

Affiliation Primate Genetics Laboratory, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany
⨯
Ann E. Mayne,

Affiliation Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Paul Dunbar,

Affiliation Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Robert Russo,

Affiliation Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Dawn M. Little,

Affiliation Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Tara Villinger,

Affiliation Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Ladawan Khowawisetsut,

Affiliation Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
⨯
Kovit Pattanapanyasat,

Affiliation Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
⨯
Francois Villinger,

Affiliations Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America, Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
⨯
Aftab A. Ansari

* E-mail: pathaaa@emory.edu

Affiliation Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯

In Vivo Administration of a JAK3 Inhibitor during Acute SIV Infection Leads to Significant Increases in Viral Load during Chronic Infection

Yoshiaki Takahashi,
Siddappa N. Byrareddy,
Christina Albrecht,
Markus Brameier,
Lutz Walter,
Ann E. Mayne,
Paul Dunbar,
Robert Russo,
Dawn M. Little,
Tara Villinger

Published: March 6, 2014
https://doi.org/10.1371/journal.ppat.1003929

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