Inducible Deletion of CD28 Prior to Secondary Nippostrongylus brasiliensis Infection Impairs Worm Expulsion and Recall of Protective Memory CD4+ T Cell Responses

Hlumani Ndlovu; Mathew Darby; Monika Froelich; William Horsnell; Fred Lühder; Thomas Hünig; Frank Brombacher

doi:10.1371/journal.ppat.1003906

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Research Article

Inducible Deletion of CD28 Prior to Secondary Nippostrongylus brasiliensis Infection Impairs Worm Expulsion and Recall of Protective Memory CD4⁺ T Cell Responses

Hlumani Ndlovu,

Affiliation International Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component and Institute of Infectious Diseases and Molecular Medicine (IIDMM), Division of Immunology, University of Cape Town, Cape Town, South Africa
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Mathew Darby,

Affiliation International Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component and Institute of Infectious Diseases and Molecular Medicine (IIDMM), Division of Immunology, University of Cape Town, Cape Town, South Africa
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Monika Froelich,

Affiliation Institute for Virology and Immunology, University of Würzburg, Würzburg, Germany
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William Horsnell,

Affiliation International Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component and Institute of Infectious Diseases and Molecular Medicine (IIDMM), Division of Immunology, University of Cape Town, Cape Town, South Africa
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Fred Lühder,

Affiliation Department of Neuroimmunology, Institute of Multiple Sclerosis Research and The Hertie Foundation, University Medical Center Göttingen, Göttingen, Germany
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Thomas Hünig,

Affiliation Institute for Virology and Immunology, University of Würzburg, Würzburg, Germany
⨯
Frank Brombacher

* E-mail: brombacherfrank@gmail.com

Affiliation International Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component and Institute of Infectious Diseases and Molecular Medicine (IIDMM), Division of Immunology, University of Cape Town, Cape Town, South Africa
⨯

Inducible Deletion of CD28 Prior to Secondary Nippostrongylus brasiliensis Infection Impairs Worm Expulsion and Recall of Protective Memory CD4⁺ T Cell Responses

Hlumani Ndlovu,
Mathew Darby,
Monika Froelich,
William Horsnell,
Fred Lühder,
Thomas Hünig,
Frank Brombacher

Published: February 6, 2014
https://doi.org/10.1371/journal.ppat.1003906

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