Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen

Nathaniel G. Jones; Elizabeth B. Thomas; Elaine Brown; Nicholas J. Dickens; Tansy C. Hammarton; Jeremy C. Mottram

doi:10.1371/journal.ppat.1003886

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Research Article

Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen

Nathaniel G. Jones,

Affiliations Wellcome Trust Centre for Molecular Parasitology and Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Elizabeth B. Thomas,

Affiliation Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Elaine Brown,

Affiliations Wellcome Trust Centre for Molecular Parasitology and Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Nicholas J. Dickens,

Affiliations Wellcome Trust Centre for Molecular Parasitology and Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Tansy C. Hammarton,

Affiliation Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Jeremy C. Mottram

* E-mail: Jeremy.mottram@glasgow.ac.uk

Affiliations Wellcome Trust Centre for Molecular Parasitology and Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯

Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen

Nathaniel G. Jones,
Elizabeth B. Thomas,
Elaine Brown,
Nicholas J. Dickens,
Tansy C. Hammarton,
Jeremy C. Mottram

Published: January 16, 2014
https://doi.org/10.1371/journal.ppat.1003886

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RNA interference
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Trypanosoma
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Cell differentiation
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Parasitic cell cycles
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Trypanosoma brucei gambiense
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Cell cycle and cell division
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